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Altering Perceptions on Psychedelics Harvard Medicine magazine While it is typical to have anxiety about the traumatic event weeks or months after it happens, people with PTSD find it difficult to perform daily functions for an extended period of time. The new techniques at Kwan’s disposal include two-photon microscopy, viral tracing and optogenetic manipulations, in which the activity of neurons can be controlled with light – all of which can be used to target functional neurons in the cortical and subcortical regions of a living mouse’s brain. It was the development of these tools at Cornell that brought Kwan back to his alma mater in 2021 after spending the last nine years in the Yale School of Medicine. Dr. Kuceyeski and Singleton and their colleagues now plan to use their approach to study the longer-term brain-dynamics effects of LSD and psilocybin—effects that would be more relevant in a clinical setting—as well as the connections between psychedelic-altered brain dynamics and